What is the maximum volume of medication that can be administered intranasally (IN) in one nare?

The maximum volume of medication that can be administered intranasally in one nare is 1 mL. This volume is supported by clinical guidelines and literature, which indicate that administering larger amounts can lead to ineffective absorption and potential overflow, as the nasal cavity has limited capacity.

When medications are delivered intranasally, the key objective is to ensure optimal absorption through the nasal mucosa while minimizing discomfort and avoiding adverse effects. If more than 1 mL is administered, there is an increased risk of the medication draining out of the nose rather than being absorbed, which can result in the patient receiving a lower effective dose. Thus, 1 mL is recognized as the safe and effective limit for intranasal administration in a single nare, ensuring both efficacy and the comfort of the pediatric patient.